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Fluorescence-guided surgery (FGS) represents a transformative advancement in modern surgical practice, leveraging near-infrared light and fluorescent dyes like indocyanine green (ICG) to enhance intraoperative visualization and decision-making. At the forefront of this evolving field is Dr. Steven D. Wexner, a globally recognized colorectal surgeon and Director of the Ellen Leifer Shulman and Steven Shulman Digestive Disease Center at Cleveland Clinic Florida. His contributions to the development and application of FGS, particularly in colorectal surgery, have been pivotal. During the 8th World Congress of Laparoscopic Surgeons (WALS) 2025, held on February 27, 2025, at The Leela Ambience Gurugram, Dr. Wexner shared critical insights as part of a consensus statement on fluorescence-guided surgery, reflecting years of research, clinical expertise, and collaborative efforts with international experts. This article delves into Dr. Wexner’s perspectives, the WALS 2025 Consensus Statement, and the broader implications of FGS in surgical innovation. Background on Fluorescence-Guided Surgery FGS is a technique that uses fluorescent agents, typically ICG, which emit light in the near-infrared spectrum when excited by specific wavelengths. This fluorescence is captured by specialized imaging systems, enabling surgeons to visualize structures and physiological processes that are invisible under traditional white light. Over the past decade, FGS has gained traction across surgical disciplines, including colorectal, oncologic, and reconstructive surgery, for applications such as assessing tissue perfusion, identifying lymphatic drainage, localizing tumors, and protecting critical anatomical structures. In colorectal surgery, one of the most promising applications of FGS is the reduction of anastomotic leaks—a devastating complication with leak rates as high as 20% in low colorectal anastomoses. By providing real-time visualization of blood flow, FGS allows surgeons to optimize anastomosis placement, potentially improving patient outcomes. Dr. Wexner has been a pioneer in exploring these applications, contributing to a growing body of evidence that underscores the safety and efficacy of FGS. Conclusion Dr. Steven D. Wexner’s insights from the WALS 2025 Consensus Statement underscore the transformative potential of fluorescence-guided surgery while highlighting the work still needed to fully realize its benefits. His leadership in colorectal surgery, combined with his collaborative efforts at WALS, positions FGS as a cornerstone of modern operative care. As of February 28, 2025, the surgical community stands at a pivotal moment—armed with a consensus framework and a call to action from one of its most respected voices. Whether through reducing complications, enhancing oncologic precision, or training the next generation, Dr. Wexner’s vision for FGS promises a future where surgeons see better to do better, ultimately improving lives one procedure at a time. Contact us: World Laparoscopy Hospital Cyber City, Gurugram, NCR Delhi, INDIA Phone/WhatsApp: +919811416838, +919999677788 World Laparoscopy Training Institute Bld. No: 27, DHCC, Dubai, UAE Phone: +971525857874 World Laparoscopy Training Institute 8320 Inv Dr, Tallahassee, Florida, USA Phone: +1 321 250 765