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A multidisciplinary team of nurses at The Mount Sinai Hospital has documented the postoperative nursing care they provided in connection with the world’s first human tracheal transplant. Their findings, published in Critical Care Nurse, will guide the meticulous nursing management of future tracheal transplant recipients. In early 2021, a team of Mount Sinai surgeons performed the single-stage long-segment tracheal transplant—an achievement that has the potential to save the lives of thousands of patients around the world who have tracheal birth defects, untreatable airway diseases, burns, tumors, or severe tracheal damage from intubation, including those who had been hospitalized with COVID-19 and placed on a ventilator. Until then, no long-term treatments existed for these patients with long-segment tracheal damage, and thousands of adults and children died each year as a result. A multidisciplinary team of nurses played a critical role in the recovery of the tracheal transplant recipient, a 56-year-old woman who received a graft from a deceased donor.