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*Acalculous cholecystitis* is a type of gallbladder inflammation *that occurs without the presence of gallstones* (unlike the more common calculous cholecystitis). Key Points: **Cause**: Often due to **gallbladder stasis**, **ischemia**, or **infection**, especially in critically ill or hospitalized patients. **Common Triggers**: Trauma Sepsis Prolonged fasting or total parenteral nutrition (TPN) Major surgery Burns ICU stays **Symptoms**: Right upper quadrant abdominal pain Fever Nausea and vomiting Signs of sepsis (in severe cases) **Diagnosis**: *Ultrasound or CT scan* may show a distended gallbladder, wall thickening, or pericholecystic fluid. *No gallstones* will be seen. Sometimes a *HIDA scan* is used to assess gallbladder function. **Treatment**: *Supportive care* (IV fluids, antibiotics) *Cholecystostomy tube* (percutaneous drainage) in unstable patients *Cholecystectomy* (surgical removal of the gallbladder) in stable or recovered patients Prognosis: Acalculous cholecystitis has a *higher risk of complications* and mortality than calculous cholecystitis, primarily because it typically occurs in very ill patients. Let me know if you want this summarized as a YouTube short script. Join Oscar Ramirez, DMSc, MSPAS, PA-C, your friendly guide through the fascinating world of gastroenterology. Whether you're curious about common digestive issues, want tips for a healthier gut, or need insights into the latest advancements in GI health, this channel is your trusted source. Explore simplified explanations of gastrointestinal conditions, from acid reflux to inflammatory bowel disease, in a way that anyone can grasp. We break down complex medical concepts into digestible bits, ensuring you leave each video with a clearer understanding of your digestive system. Discover practical tips for maintaining optimal gut health through diet, lifestyle changes, and preventive measures. At Gastroenterology Simplified, we're not just a channel; we're a community. Share your questions, experiences, and insights in the comments below each video. Let's create a supportive space where everyone can learn and grow together.