How to Investigate Behavior and Cognitive Abilities of Individual Rodents in a Social Group скачать в хорошем качестве

How to Investigate Behavior and Cognitive Abilities of Individual Rodents in a Social Group

This webinar focused on behavioral phenotyping of rodents by automated cage-system. Presenters Dr. Ewelina Knapska, Dr. David Wolfer, and Dr. Holger Russig provide insights into high-throughput cognition testing of individual rodents within their social environment, discussing how this supports increased animal welfare and decreased data variability and workload for the researcher. During this exclusive webinar sponsored by TSE Systems, presenters review automated home-cage behavioral phenotyping using the IntelliCage system and discuss several research applications including the study of hippocampus-dependent spatial learning tasks, measuring motor impulsivity, studying the role of MMP-9 in the central amygdala in learning of appetitively and aversively motivated behaviors, and assessing cognitive rigidity in a mouse models of autism. After establishing basic concepts, presenters demonstrate how freely programmable behavioral tasks can be controlled and how to link them to established paradigms performed in biomedical and basic behavioral, neurobiological, psychiatric, pharmacological and genetic research. The implications for understanding therapeutic strategies is also discussed. Key Topics: how to transfer concepts of established behavioral paradigms into the automated home-cage phenotyping simultaneous monitoring of different measures of mouse behavior comparing different behaviors in well-balanced conditions the involvement of MMP-9 in the central amygdala in learning of appetitively and aversively motivated behaviors prescreening of subjects using spontaneous behavior during adaptation to optimize cognitive tests hippocampus-dependent spatial learning tasks