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#type3 #hypersensitivity #immuneresponse #classification #GeneralisedReactions #SystemicReactions #SerumSickness #AplasticAnaemia #ClinicalPresentation #patientmanagement #atgshorts #reactions #fundamentals #immunesystem #rheumatoidarthritis #SystemicLupusErythematosus #PolyarteritisNodosa #PostStreptococcalGlomerulonephritis #SerumSickness #ArthusReaction #FarmersLung #HypersensitivityPneumonitis #ChronicHypersensitivityPneumonitis #SjögrensSyndrome #MixedCryoglobulinemia #ReactiveArthritis #sarcoidosis #SubacuteBacterialEndocarditis #ChronicActiveHepatitis Hypersensitivity Reactions Type 3 | Part 1 Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $59 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/ --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 1000+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ 00:00:00 Basic fundamentals of Type III Hypersensitivity Reactions 00:04:10 Classification of Type III Hypersensitivity Reactions 00:05:00 Overview of Generalized/Systematic Reactions 00:05:29 What are serum sickness-like reactions? 00:06:46 Clinical presentation of a patient with Aplastic Anemia 00:17:49 What are the key considerations in managing patients with aplastic anemia? 00:22:17 How do Serum Sickness/Type III Hypersensitivity reactions occur? 00:23:53 How do ATGs trigger serum sickness-like reactions or Type III hypersensitivity reactions, and what is the detailed process behind the formation and deposition of immune complexes? Type III hypersensitivity, in the Gell and Coombs classification of allergic reactions, occurs when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response and attraction of leukocytes. There are three steps that lead to this response.[1] The first step is immune complex formation, which involves the binding of antigens to antibodies to form mobile immune complexes. The second step is immune complex deposition, during which the complexes leave the plasma and are deposited into tissues. Finally, the third step is the inflammatory reaction, during which the classical pathway is activated and macrophages and neutrophils are recruited to the affected tissues. Such reactions may progress to immune complex diseases. --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to the perks: Sign up now on our website at https://members.drnajeeblectures.com/ Follow us on Facebook:- / drnajeeb Follow us on Instagram:- / drnajeeblectures