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Dr. Arndt Happe, Germany - MIS Global Conference, Barcelona 2016. In the maxillary anterior area, the esthetic outcome is a critical determinant in the overall success of implant therapy and yet remains a challenge. Besides osseointegration, long lasting soft tissue integration is a key factor for implant success, but restorative components may interact with the peri-implant soft tissue that serves as a biological seal and have an impact on the outcome. This peri-implant restorative interface is a highly relevant subject for scientific research, as it may be the key to longevity of implant restorations and sustainability of implant esthetics. Different factors have been identified and reported to interact with the peri-implant tissues, respectively influence the vertical localization of the crestal bone and the dimension and localization of the peri-implant soft tissues. These are the individual morphotype, the peri- implant tissue quality, the restorative environment, and the property of the abutment, including nature of the abutment connection. The presentation will give an overview of the main factors that may influence the outcome of esthetic implant treatments. It will show proofed protocols that allow for successful treatment of demanding patients. For more information, visit MIS Website: www.mis-implants.com