'Yeastern' Medicine: brew nightshade drugs w/ genetically modified yeast and whole-cell engineering скачать в хорошем качестве

'Yeastern' Medicine: brew nightshade drugs w/ genetically modified yeast and whole-cell engineering

Plant-derived medicines are prone to shortages because their agriculture-based supply chains are vulnerable to geopolitical and environmental factors. Recreating biosynthesis of these medicines in a scalable organism like Baker’s yeast (Saccharomyces cerevisiae) provides an economical, resilient alternative to plant cultivation. One such medicine is Tropane alkaloids (TAs), which are neurotransmitter receptor inhibitors produced by nightshade plants and are classified as essential medicines by the World Health Organization for treating neuromuscular disorders. In this webinar, we hear from Prashanth Srinivasan, who along with his colleagues at Stanford have developed a proof-of-concept ‘biomanufacturing’ platform for the production of TA medicines, hyoscyamine and scopolamine. In this webinar you will.. -Learn how functional genomics was used to discovery the final missing enzyme in the pathway -See how the technology was used to produce two classes of novel TA derivatives in yeast. -Look at the final platform, which incorporates over 30 additional enzymes expressed across six cellular locations and constitutes a starting point for the development of a new TA supply chain via microbial biomanufacturing