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Some people wonder whether fragments of foreign DNA from bacteria, food, or even vaccines can damage our DNA? This animation describes why it is virtually impossible. Our DNA resides in the nucleus of our cells in the form of chromosomes. But even before getting to the nucleus, a foreign fragment of DNA would first have to breach the cell's outer membrane. Cells have multiple ways to identify and destroy foreign material, including foreign DNA fragments. Sometimes a cell will even destroy itself to protect us. Even if a foreign DNA fragment could get into the cell and is not destroyed, it would still need to get into the nucleus to mix with our DNA, and the nucleus has its own protective mechanisms to prevent this from happening as well. In sum, our cells have many protective layers to prevent foreign DNA from damaging our own DNA. This animation was created by and for the Annenberg Public Policy Center at the University of Pennsylvania in collaboration with the Vaccine Makers Project (VMP), the classroom-based program of the Vaccine Education Center at Children’s Hospital of Philadelphia (VEC at CHOP) and XVIVO Scientific Animation. Copyright © 2024, Annenberg Public Policy Center. All rights reserved. Visit these websites for more information: Learn more about the Annenberg Public Policy Center, home of FactCheck.org and SciCheck: https://www.annenbergpublicpolicycent.... Access the VMP’s free classroom materials: https://vaccinemakers.org. Find information and resources related to vaccines and their safety: http://vaccine.chop.edu. Learn more about XVIVO’s medical animations and scientific media: https://xvivo.com.