A Novel Blood-Based Biomarker for Silent Cerebral Edema and Brain Vascular Injury скачать в хорошем качестве

A Novel Blood-Based Biomarker for Silent Cerebral Edema and Brain Vascular Injury

Presented By: Jason D. Hinman, PhD, MD Speaker Biography: Dr. Jason D. Hinman is a physician-scientist and Associate Professor and Vice Chair of Research in the Department of Neurology in the David Geffen School of Medicine at the University of California Los Angeles. Dr. Hinman completed his combined MD/PhD degree with graduate training in Molecular Medicine at Boston University School of Medicine in 2007 after graduating with a B.A. in Psychology from Case Western Reserve University in Cleveland, Ohio. After completing adult neurology residency and stroke fellowship training at UCLA, Dr. Hinman was among the first physician-scientists to complete post-residency research training as part of the NINDS R25 Translational Neuroscience Fellowship Program. At UCLA, the Hinman Lab is focused on the molecular interface of disease pathways integral to stroke, cerebrovascular disease, and dementia. The lab uses animal models of stroke and dementia together with gliovascular cell profiling to identify novel pathways and biomarkers for cerebral small vessel disease. Webinar: A Novel Blood-Based Biomarker for Silent Cerebral Edema and Brain Vascular Injury Webinar Abstract: Emerging data from several expansive clinical trials indicates that common chronic vascular risk factors such as diabetes, hypertension, obesity, and age increase the risk of stroke and dementia. This increased risk occurs through direct injury to brain blood vessels resulting from these risk factors and causes brain blood vessel leakage, cerebral edema, and ultimately permanent brain tissue injury. There are currently no clinical biologic assays to directly measure brain blood vessel health. Widely available imaging techniques provide limited quantitative information and only indicate cerebrovascular damage that has already occurred. To develop a blood-based biomarker for early brain vascular injury, we utilized a custom Luminex multiplex assay to measure the serum/plasma levels of six inflammatory molecules in two patient cohorts. In both discovery and validation cohorts (n=298 total), levels of the six defined circulating inflammatory molecules were not only associated with permanent vascular brain injury as measured by T2/FLAIR MRI signal intensity but also with cerebral free water, a diffusion tensor MRI measure of cerebral edema. Earn PACE Credits: 1. Make sure you’re a registered member of LabRoots https://www.labroots.com/virtual-even... 2. Watch the webinar on YouTube or on the LabRoots Website https://www.labroots.com/webinar/nove... 3. Click Here to get your PACE credits (Expiration date – August 25, 2023): https://www.labroots.com/credit/pace-... LabRoots on Social: Facebook:   / labrootsinc   Twitter:   / labroots   LinkedIn:   / labroots   Instagram:   / labrootsinc   Pinterest:   / labroots   SnapChat: labroots_inc