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For this Grand Rounds, we have another Clinical Problem Solving (CPS) case to allow listeners to watch in real time how master clinicians reason through challenging cases. While getting the diagnosis “right” is amazing to see, the true learning comes from witnessing how experts navigate the zigs and zags of a diagnostic journey in a case that unfurls in real time (as it does in life, of course). Our discussant will be Lisa Winston, MD, professor in the Division of HIV, ID, and Global Medicine, chief of the Medical Staff and hospital epidemiologist at ZSFG, and Master Clinician. She received her MD from Johns Hopkins University School of Medicine, completed her Internal Medicine residency, Chief Residency, and fellowships in Infectious Diseases and Clinical Pharmacology at UCSF. Her research interests are infection control and prevention and antimicrobial resistant bacterial pathogens. Following the case discussion, an expert panel will offer some key teaching points based on the case prepared by Parnassus Chief Residents Anna Fretz, MD, MHS and Viridiana Garcia, MD, MS. Note: Closed captions will be available within 48-72 hours after posting. Program Lekshmi Santhosh: Introduction 00:02:09-00:33:09 – Clinical Problem Solving with Lisa Winston (professor in the Division of HIV, ID, and Global Medicine, chief of the Medical Staff and hospital epidemiologist at ZSFG) 00:33:09-01:01:08 – Discussion with Natasha Spottiswoode, MD, D.Phil, (clinical fellow in Infectious Diseases at UCSF Health), Joe DeRisi, PhD, (professor in Biochemistry and Biophysics and Howard Hughes Investigator at UCSF Health), and Michael Wilson, MD, (associate professor in Neurology at UCSF Health) See previous Medical Grand Rounds: • October 6: Unlocking the Mysteries of Long COVID • Clinical Problem Solving • September 29: Stem Cell Transplants and Emerging Cellular Therapies for Cancer: Challenges and Opportunities • Stem Cell Transplants and Emerging Cellula... • September 22: AI for Computational Imaging in Medicine: Promise, Pitfalls, and What's Next • AI for Computational Imaging in Medicine: ... • September 15: A Fireside Chat with Renowned Pandemic Expert Michael Osterholm • A Fireside Chat with Renowned Pandemic Exp... See all UCSF Covid-19 grand rounds, which have been viewed over 3M times, at • UCSF Department of Medicine Medical Grand ... .