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This short Double Take video from the New England Journal of Medicine emphasizes the importance of remaining vigilant in broadening the differential diagnosis when clinical cases evolve atypically. Focusing on a patient whose diagnosis was delayed, the video guides viewers through the sequential clinical events that required additional diagnostic evaluation, culminating in the final diagnosis. This video is based on a Clinical Problem-Solving article published in NEJM (Hard to Swallow, by M.J. Litt et al., https://www.nejm.org/doi/full/10.1056..., in the October 7, 2021, issue), and the companion Interactive Medical Case (https://www.nejm.org/doi/full/10.1056..., in the September 30, 2021, issue). The New England Journal of Medicine is the world’s leading general medical journal. Continuously published for over 200 years, NEJM publishes peer-reviewed research along with interactive clinical content for physicians, educators, and the global medical community at NEJM.org.