Repeat Biosynthetic Pathways despite Genome Reduction скачать в хорошем качестве

Repeat Biosynthetic Pathways despite Genome Reduction

Secondary metabolites, which are small-molecule organic compounds produced by living organisms, provide or inspire drugs for many different diseases. These natural products have evolved over millions of years to provide a survival benefit to the producing organism and often display potent biological activity with important therapeutic applications. For instance, defensive compounds in the environment may be cytotoxic to eukaryotic cells, a property exploitable for cancer treatment. Here, we describe the genome of an uncultured symbiotic bacterium that makes such a cytotoxic metabolite. This symbiont is losing genes that do not endow a selective advantage in a hospitable host environment. Secondary metabolism genes, however, are repeated multiple times in the genome, directly demonstrating their selective advantage. This finding shows the strength of selective forces in symbiotic relationships and suggests that uncultured bacteria in such relationships should be targeted for drug discovery efforts. DOI: https://doi.org/10.1128/mSystems.0009.... Title: Increased Biosynthetic Gene Dosage in a Genome-Reduced Defensive Bacterial Symbiont Authors: Juan Lopera Ian J. Miller Kerry L. McPhail Jason C. Kwan (http://orcid.org/0000-0001-9933-1536) Editor: Steven J. Hallam Published in mSystems® on 21 November 2017 👍 Subscribe to ASM's YouTube channel at https://goo.gl/mOVHlK 🔬 Learn more about the American Society for Microbiology at http://www.asm.org ✅ Become a member today at http://www.asmscience.org/join 📱 Interact with us on social at: Facebook Show your support and get updates on the latest microbial offerings and news from the ASM.   / asmfan   ASM International Facebook Groups Join an ASM International Facebook Group and connect with microbiologists in your region. http://www.asm.org/index.php/programs... Twitter Follow all the latest news from the Society.   / asmicrobiology   Instagram Outstanding images of your favorite viruses, fungi, bacteria and parasites   / asmicrobiology