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In this video, Dr Vidushi Sharma & Dr Suresh K Pandey (SuVi Eye Institute, Kota India) demonstrate botulinum toxin injection to manage severe blepharospasm. Blepharospasm is a common eye condition that is characterized by spasms of the upper and/or lower eyelid that cause the eye to shut involuntarily. In some patients, severe and chronic blepharospasm can cause functional blindness, as the patient may be unable to keep his eyelids open. Botox/Botogenie has been used for decades to treat blepharospasm, and it is the treatment of choice .BOTOGenie® is a biologically active and highly purified preparation of Botulinum toxin Type A. This is an extremely potent neurotoxin complex which causes relaxation of muscles, marked reduction in sweat gland secretory activity and silencing of nociceptor function on its absorption. The medical science has developed methodology to derive magical drug effect by unique formulation and controlled administration techniques. It has been used to correct undesirable muscular activity for a considerable period without surgical intervention. This action is reversible in nature in a few months. Since BOTOGenie® is in a highly purified form & is used in minute quantities, it does not induce any immunological response even after several treatments in most subjects. BOTOGenie® has unique pharmacological properties as a neuromuscular blocking agent. It acts by inhibiting the release of acetylcholine resulting in partial & local inactivation of muscle activity. This effect usually lasts for 4-6 months when it needs to be redone. Thus it helps to reduce some of the diseased conditions caused by abnormal muscular contraction e.g. Hemifacial spasms, Cerebral Palsy etc. The action is dose related to large extent.This unique muscle relaxation property of Botulinum toxin Type A has been most exploited for cosmetic correction of facial defects ( due to contraction of group of muscles ) like Glabeller lines, Forehead skin folds, Crow feet effect near lateral side of eyes & other facial wrinkles. Marked reduction in sweat gland secretory activity (Hyperhydrosis-Palmer, Axilla) and silencing of nociceptor function for relief from pain (Migraine, Chronic pain, Neck pain etc.) have been achieved.Botulinum toxin Type A has been used with excellent results to correct the above diseased conditions and many more like Spasmodic dysphonia, Drooling saliva, Speech & Voice disorder, Achlasia etc. Contact Details; Dr Suresh K Pandey, Dr Vidushi Sharma Suvi Eye Institute and Research Center, VISX™ Advanced CustomVue™ Lasik Laser Center, C 13 Talwandi, Kota, Rajasthan, India; Phone +91 (744) 2433575; +91 9351412449; E-mail- [email protected], www.suvieye.com