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Neuromuscular Junction | Structure , Function & Diseases🩺

#NeuromuscularJunction #SynapticCleft #MyastheniaGravis Neuromuscular Junction | Structure , Function & Diseases🩺 Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 800+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $99 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/ --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 800+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ 00:00:00 Neuromuscular Transmission & release of chemical neurotransmitter in Motor End Plate. Conversion of Chemical message into Electrical message. Neuro Muscular Junction (NMJ); defining & location. "How the motor neurons talk to the muscles" 00:06:27 Neurotransmitters (NTs); their storage in Motor Nerve Ending (MNE). Post-Synaptic membrane; definition of synapse. Neuro Muscular Junction (NMJ); role as "chemical synapses". Pre- and Post-Synaptic membrane; Pre synaptic membrane will "talk" and post-synaptic will "listen". A "one-way" transmission not two-way; since only in one direction. 00:09:26 Acetylcholine (ACh); storage in vesicles. Synthesis of Vesicles in Cell Body of neurons in the Spinal Cord; proteins as a principle only synthesized in neuronal cell bodies. ACh synthesized in the Nerve Ending; Nerve Ending as a “semi-autonomous” unit; capable of NT synthesis. 00:16:14 Synthesis of Ach in detail; role of “Choline transporters”, Acetyl CoA & Choline Acetyl Transferase (CAT) enzyme. Storage & concentration of of ACh in vesicles; stored as “chemical signaling molecules”. 00:21:53 1-Action Potential; its mechanism of generation & role of voltage-gated Na-channels; Na influx 2-Ca+ channels; role of “Ca-sensitive proteins” 3-Fusion of Vesicular membrane with pre-synaptic membrane triggered as a result of Ca influx; Ach release into the SYNAPTIC CLEFT; Exocytosis of Neurotransmitter. SYNAPTOBREVIN & SYNTEXIN; role in Ach release. Classification of above 3 as steps of PRE-SYNAPTIC EVENTS on NM Junction. 00:30:40 Movement of Ach from Pre-synaptic Membrane to Post-Synaptic Membrane (SYNAPTIC CLEFT) through diffusion. ACh sensitive Receptors/channels on post-synaptic membrane; their role as “ears of the muscles”. NICOTINIC CHOLINERGIC channels (NCC); Resting Membrane Potential (RMP) & importance of heavy Na+ influx in depolarization of post-synaptic membrane. 00:41:37 MOTOR-END PLATE (MEP) POTENTIAL & Miniature End Plate Potential concept. MEP potential & Action Potential compared. Depolarization spreading to flanks of post-synaptic membrane. Action Potential triggering in Voltage-gated Na+ channels in the flanks. Reaching of Threshold Potential & spreading of wave of depolarization. 00:49:20 Revision of basic concept of NM Transmission at NMJ. "Talking" of neurons completed. 00:53:36 ACETYL-CHOLINESTERASES; their role in breaking of Ach; & termination of its action. 00:58:50 CLATHRINS proteins; vesicle formation role in recycling of choline. 01:01:15 MYASTHENIA GRAVIS: Autoantibodies attaching to Nicotinic Cholinergic Receptors (NCR) at NMJ. NEUROMUSCULAR TRANSMISSION BLOCKADE due to Anti-cholinergic antibodies attaching at Nicotinic Cholinergic Receptors. TREATMENT: Acetylcholinesterase inhibitor/blocker (AchI) resulting in increased no of Ach in NMJ. Physostigmine, Neostigmine 01:09:11 EATON LAMBART MYASTHENIC SYNDROME; autoimmune disease; works by blocking Ca+ channels on pre-synaptic NMJ. Differentiating b/w Myasthenia & Eaton Lambert: Weakness and/or difficulty in initiating movement in both. --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to perks: Sign up now on our website at https://members.drnajeeblectures.com/...    / @doctornajeeb   Follow us on Facebook :-   / drnajeeb   Follow us on Instagram :-   / drnajeeblectures