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What happens when Microsoft builds a superintelligence team—but doesn’t chase AGI? Instead, they point their smartest minds at one thing: helping doctors diagnose disease. In this episode, we riff on the strategy behind that decision—and why narrow, high-stakes AI might be the smartest kind. Kyle, Mario, and Rob unpack Microsoft’s approach to human-in-the-loop AI, the business model implications of medical breakthroughs, and what it means when AI becomes part of the healthcare supply chain. But things get personal, too: What happens when profit motives clash with cures? Can AI be a tool for humanity if it’s built by corporations? We also explore: The slow pivot away from generalist AI toward specialist agents Open-source cellular modeling and the open-access vs. monetized AI debate The latest dev tools, including Cursor’s multi-step agent pipeline And yeah, we check in on Copilot, take a quick detour into Ask Jeeves nostalgia, and pitch a new hit show: Diagnosis: AI. A big episode on the future of medicine, money, and the role of humans in AI’s last mile.