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Bench to Bedside: Myelination 1 - Myelination, Remyelination and Multiple Sclerosis - Mikael Simons ΡΠΊΠ°Ρ‡Π°Ρ‚ΡŒ Π² Ρ…ΠΎΡ€ΠΎΡˆΠ΅ΠΌ качСствС

Bench to Bedside: Myelination 1 - Myelination, Remyelination and Multiple Sclerosis - Mikael Simons 7 years ago

myelin

myelination

demyelination

remyelination

multiple sclerosis

MS

neurodegenerative disease

neurodegeneration

oligodendrocytes

НС удаСтся Π·Π°Π³Ρ€ΡƒΠ·ΠΈΡ‚ΡŒ Youtube-ΠΏΠ»Π΅Π΅Ρ€. ΠŸΡ€ΠΎΠ²Π΅Ρ€ΡŒΡ‚Π΅ Π±Π»ΠΎΠΊΠΈΡ€ΠΎΠ²ΠΊΡƒ Youtube Π² вашСй сСти.
ΠŸΠΎΠ²Ρ‚ΠΎΡ€ΡΠ΅ΠΌ ΠΏΠΎΠΏΡ‹Ρ‚ΠΊΡƒ...
Bench to Bedside: Myelination 1 - Myelination, Remyelination and Multiple Sclerosis - Mikael Simons
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Π£ нас Π²Ρ‹ ΠΌΠΎΠΆΠ΅Ρ‚Π΅ ΠΏΠΎΡΠΌΠΎΡ‚Ρ€Π΅Ρ‚ΡŒ бСсплатно Bench to Bedside: Myelination 1 - Myelination, Remyelination and Multiple Sclerosis - Mikael Simons ΠΈΠ»ΠΈ ΡΠΊΠ°Ρ‡Π°Ρ‚ΡŒ Π² максимальном доступном качСствС, Π²ΠΈΠ΄Π΅ΠΎ ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ΅ Π±Ρ‹Π»ΠΎ Π·Π°Π³Ρ€ΡƒΠΆΠ΅Π½ΠΎ Π½Π° ΡŽΡ‚ΡƒΠ±. Для Π·Π°Π³Ρ€ΡƒΠ·ΠΊΠΈ Π²Ρ‹Π±Π΅Ρ€ΠΈΡ‚Π΅ Π²Π°Ρ€ΠΈΠ°Π½Ρ‚ ΠΈΠ· Ρ„ΠΎΡ€ΠΌΡ‹ Π½ΠΈΠΆΠ΅:

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Bench to Bedside: Myelination 1 - Myelination, Remyelination and Multiple Sclerosis - Mikael Simons

https://www.ibiology.org/human-diseas... Improving our understanding of nerve cell myelination and remyelination in both animal models and humans may to improve treatment for demyelinating diseases such as multiple sclerosis. Β  Part 1: Myelination, Remyelination and Multiple Sclerosis: During multiple sclerosis, the myelin sheath around axons is destroyed and nerve function is lost. Β Yet sometimes a few lesions undergo remyelination. Β Why? And how can this be improved? Β  Part 2: Neuropathology of Multiple Sclerosis: Better understanding of the brain pathology that correlates with the progression of multiple sclerosis may improve diagnosis and treatment. Talk Overview: Multiple sclerosis (MS) is a debilitating autoimmune disease in which immune cells infiltrate the central nervous system and attack the myelin sheath surrounding axons. Β Dr. Simons explains that myelin is necessary for signal conduction by nerve cells and for the metabolic support of axons. Demyelination results in axonal loss and formation of lesions in the brain. A small percentage of MS lesions are capable of remyelination following steps similar to axonal myelination during normal development. Β Since lesion remyelination correlates with reduced neurodegeneration, Simons and his colleagues strive to understand why remyelination occurs in only a small number of MS patients and to identify drugs that may promote it. Β Β  MS begins as a disease of intermittent episodes with recovery in between. With time, however, MS changes to a progressive disease with increasing disability. Β In her talk, Dr. Stadelmann explains that studies of MS brain lesions have identified specific changes that occur with disease progression. For example, chronic MS lesions contain many fewer oligodendrocytes than do early lesions. Β Since oligodendrocytes produce the myelin sheath that surrounds axons, drugs that stimulate the migration and establishment of oligodendrocytes in lesions may increase axonal remyelination and improve the prognosis of MS patients. Stadelmann also explains that brain lesions can be caused by conditions other than MS, such as neuromyelitis optica. Β Improved studies will help to correctly diagnose and treat these distinct diseases. Β  About Mikael Simons: Dr. Simons’ research focuses on developing new ways to promote remyelination of damaged axons in demyelinating diseases such as multiple sclerosis (MS). To reach this goal, his lab strives to better understand the cellular processes underlying myelin formation in normal development. Β  Simons received his MD from the University of Heidelberg and did his residency in neurology at the University of TΓΌbingen. He joined the University of GΓΆttingen in 2004 and, in 2016, he moved to Munich to become Director of the Institute of Neuronal Cell Biology at the Technical University, and the German Center for Neurodegenerative Diseases. Learn more about Dr. Simons’ research here: http://www.neuroscience.med.tum.de/in... About Christine Stadelmann: Dr. Stadelmann is a Professor and Deputy Director of the Institute for Neuropathology at the University of GΓΆttingen Medical Center. Β Her studies focus on inflammatory diseases of the central nervous system including multiple sclerosis and neuromyelitis optica. She is particularly interested in understanding which pathological events correlate with disease progression. Learn more about Dr. Stadelmann’s research here: http://www.neuropathologie.med.uni-go...

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