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Watch the Full Video at https://www.jove.com/v/50533/multi-sc.... Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo - a 2 minute Preview of the Experimental Protocol Nihal E. Vrana, Agnes Dupret-Bories, Christophe Chaubaroux, Elisabeth Rieger, Christian Debry, Dominique Vautier, Marie-Helene Metz-Boutigue, Philippe Lavalle INSERM, Biomatériaux et Bioingénieriee; Hôpitaux Universitaires de Strasbourg, Service Oto-Rhino-Laryngologie; Université de Strasbourg, Faculté de Chirurgie Dentaire; In this video, we will demonstrate modification techniques for porous metallic implants to improve their functionality and to control cell migration. Techniques include development of pore gradients to control cell movement in 3D and production of basement membrane mimics to control cell movement in 2-D. Also, a HPLC-based method for monitoring implant integration in-vivo via analysis of blood proteins is described. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments