Metabolism Of Glycine, Leucine, Isoleucine, Valine, Arginine and Histidine скачать в хорошем качестве

Metabolism Of Glycine, Leucine, Isoleucine, Valine, Arginine and Histidine

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:-   / drgbhanuprakash   📌𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺 𝗖𝗵𝗮𝗻𝗻𝗲𝗹 𝗛𝗲𝗿𝗲:- https://t.me/bhanuprakashdr 📌𝗦𝘂𝗯𝘀𝗰𝗿𝗶𝗯𝗲 𝗧𝗼 𝗠𝘆 𝗠𝗮𝗶𝗹𝗶𝗻𝗴 𝗟𝗶𝘀𝘁:- https://linktr.ee/DrGBhanuprakash Metabolism of Glycine, Leucine, Isoleucine, Valine, Arginine, and Histidine Amino acids are essential building blocks for proteins and play diverse roles in cellular metabolism. The metabolism of specific amino acids involves intricate biochemical pathways. Here's an overview of the metabolism of glycine, leucine, isoleucine, valine, arginine, and histidine: Glycine Metabolism: Glycine is a simple amino acid that serves as a precursor for various important molecules. It can be synthesized from serine through the action of serine hydroxymethyltransferase. Glycine is a component of heme, glutathione (an antioxidant), and creatine. It is also involved in the synthesis of purines, the building blocks of DNA and RNA. Leucine, Isoleucine, and Valine Metabolism (Branched-Chain Amino Acids): Leucine, isoleucine, and valine are branched-chain amino acids (BCAAs) that share common metabolic pathways. BCAAs are essential amino acids, meaning they must be obtained from the diet. They are primarily catabolized in skeletal muscle. The breakdown of BCAAs yields acetyl-CoA and succinyl-CoA, which enter the citric acid cycle (Krebs cycle) to generate energy. Branched-chain ketoacid dehydrogenase (BCKDH) is the key enzyme in this process. Arginine Metabolism: Arginine is a semi-essential amino acid involved in various metabolic pathways. It serves as a precursor for nitric oxide (NO), a potent vasodilator important for blood vessel function. Arginine can be metabolized to ornithine and urea in the urea cycle, which helps remove excess ammonia from the body. Additionally, arginine is a substrate for the synthesis of creatine, polyamines, and proline. Histidine Metabolism: Histidine is an essential amino acid used for protein synthesis. It is a precursor for histamine, a neurotransmitter and immune system mediator. Histidine can also be converted to urocanic acid and then to glutamate, entering the citric acid cycle for energy production. Clinical Significance: Abnormalities in the metabolism of these amino acids can lead to various metabolic disorders. For example, maple syrup urine disease (MSUD) results from a deficiency in the enzymes responsible for BCAA catabolism. Hyperargininemia is characterized by high levels of arginine in the blood due to defects in the urea cycle enzymes. Disorders related to the metabolism of histidine, such as histidinemia, are generally benign but can cause elevated histidine levels in the blood and urine. #fmge #fmgevideos #rapidrevisionfmge #fmgejan2023 #mbbslectures #nationalexitexam #nationalexittest #neetpg #usmlepreparation #usmlestep1 #fmge #usmle #drgbhanuprakash #medicalstudents #medicalstudent #medicalcollege #neetpg2023 #usmleprep #usmlevideos #usmlestep1videos #medicalstudents #neetpgvideos #biochemistry #biochemistryvideos #biochemistrynotes #biochemistrymbbs #biochemistryusmle #biochemistryneetpg