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In this online lecture, we will delve into the world of Cushing's Syndrome - a hormonal disorder caused by excessive levels of cortisol hormone. We will explore the etiology, clinical features, and diagnosis of this condition, and discuss available treatment options, including surgery, radiation therapy, and medications. Join us to learn more about this complex disorder and its management. ▬ 📌 Cushing's Syndrome ▬▬▬▬▬▬▬▬▬▬ Cushing's Syndrome is a hormonal disorder caused by prolonged exposure to high levels of cortisol hormone in the body. Cortisol is a hormone that helps regulate blood sugar levels, blood pressure, immune function, and other important processes in the body. Cushing's Syndrome is named after Harvey Cushing, the physician who first described the condition in 1912. 👉 Etiology and Pathogenesis Cushing's Syndrome can be caused by a variety of factors, including: 📍Pituitary adenoma: A non-cancerous tumor in the pituitary gland that secretes excessive amounts of adrenocorticotropic hormone (ACTH), which in turn stimulates the adrenal glands to produce too much cortisol. 📍Adrenal adenoma or carcinoma: A non-cancerous or cancerous tumor in one or both adrenal glands that produces too much cortisol. 📍Ectopic ACTH-producing tumor: A tumor that produces ACTH outside of the pituitary gland, which can lead to excessive cortisol production. 📍Long-term use of glucocorticoid medications: Such as prednisone or dexamethasone, can cause Cushing's Syndrome in some cases. 👉 Clinical Features The signs and symptoms of Cushing's Syndrome can vary widely, but some of the most common include: ✦ Weight gain, particularly in the upper body and face ✦ Moon face: A rounded, swollen face. ✦ Buffalo hump: A fatty hump between the shoulders ✦ Purple stretch marks on the skin ✦ Thin skin that bruises easily ✦ Slow healing of wounds ✦ Acne or other skin infections ✦ Muscle weakness ✦ High blood pressure ✦ Diabetes or impaired glucose tolerance ✦ Menstrual irregularities or infertility in women ✦ Reduced sex drive and erectile dysfunction in men. 👉 Diagnosis Diagnosing Cushing's Syndrome can be challenging, as the signs and symptoms can be caused by many other conditions. Some of the tests that may be used to diagnose Cushing's Syndrome include: 📍24-hour urine cortisol test: Measures the amount of cortisol in the urine over a 24-hour period. 📍Late-night salivary cortisol test: Measures cortisol levels in saliva. 📍Low-dose dexamethasone suppression test: Measures cortisol levels after taking a low dose of the steroid medication dexamethasone. 📍High-dose dexamethasone suppression test: Measures cortisol levels after taking a high dose of dexamethasone. 📍ACTH stimulation test: Measures cortisol levels after receiving an injection of ACTH. 👉Differential Diagnosis Cushing's Syndrome can be mistaken for other conditions that cause similar symptoms, such as: 🔸Obesity 🔸Polycystic ovary syndrome (PCOS) 🔸Diabetes 🔸Metabolic syndrome 🔸Depression 👉Treatment The treatment of Cushing's Syndrome depends on the underlying cause. If the condition is caused by the long-term use of glucocorticoid medications, the dose may need to be reduced or discontinued. In cases where a tumor is causing excessive cortisol production, surgery to remove the tumor may be necessary. Radiation therapy and medications may also be used to treat Cushing's Syndrome. In summary, Cushing's Syndrome is a hormonal disorder caused by excessive cortisol production. It can be caused by a variety of factors, including tumors and long-term use of glucocorticoid medications. The signs and symptoms can be wide-ranging, and the condition can be challenging to diagnose. Treatment depends on the underlying cause and may involve surgery, radiation therapy, or medications. ▬ 🎬 5500+ sqadia.com Medical Videos ▬▬▬▬▬▬▬▬▬▬ 👩🏻⚕️ Accessible Medical Student Education 24/7/365 💡 Simplifying Medical Learning 💪 Study Hard, Dream Big, Achieve More