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The liver, muscle, brain, and adipose tissue all play their own give and take when it comes to metabolism. Subscribe to Nourishable at / nourishable This video is part 1 of the Systemic Metabolism module within a lecture series on the nutrition science of macronutrients. Systemic Metabolism Lecture playlist: • Systemic Metabolism Macronutrients Lecture playlist: • Macronutrients Lectures Follow Nourishable on twitter, facebook and instagram to stay up to date on all things nutrition. / nourishable fb.me/nourishable.tv / nourishable Lecture Development, Hosting & Post-Production by Lara Hyde, PhD http://www.nourishable.tv Video Production by Robbie Hyde / chedderchowder Opening Motion Graphics by Jay Purugganan https://www.c9studio.com/WP/ The information in this video is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images and information, contained on or available through this video is for general information purposes only. References Chapter 9 Wardlaw’s Perspectives in Nutrition, 2019 (Editors: Byrd-Bredbenner, Moe, Berning and Kelley, 11th edition) Chapter 5 Modern Nutrition in Health and Disease, 2014 (Editors: Ross, Caballero, Cousins, Tucker, and Ziegler; 11th edition) Chapter 7 Gropper & Smith, Advanced Nutrition and Human Metabolism, 7th Edition, 2018 Not all organs can perform all metabolic pathways! The liver is a master regulator in metabolism. The liver can perform glycogenesis, glycogenolysis, gluconeogenesis, lipogenesis, ketogenesis, protein synthesis especially for plasma proteins, deamination, and urea synthesis. The liver primarily uses fatty acids as fuel, but can also use glucose and amino acids. The brain requires glucose for fuel and CANNOT use fat, though it can adapt to ketones. The muscle can perform glycogenesis and glycogenolysis, however it is rather selfish and would keep all the glucose released from glycogen for itself. Muscle can use glucose, fatty acids, or ketones as fuel, but primarily uses fatty acids at rest and glucose when exercising. Muscle can activate the lactic acid system during high intensity activity. The adipose (fat) tissue can perform lipolysis, lipogenesis, and acts as the major site for triglyceride storage. Adipose primarily uses glucose as fuel, but can also use fatty acids.