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Lecture in the C-STAR series, delivered by Joseph R. Duffy, PhD (Prof. Em., Mayo Clinic), on October 8th, 2020. Title: Primary progressive apraxia of speech: What is it and what is it teaching us? Abstract: This presentation will address a recently identified neurodegenerative clinical syndrome known as primary progressive apraxia of speech (PPAOS). The salient features of PPAOS will be reviewed, with illustrative cases, as will the research that has defined its demographics, associated neurologic deficits, evolution over time, and neuroimaging and histopathological correlates. Implications of these findings for our understanding of speech motor planning and programming, and its breakdown, will be discussed. Brief Bio: Joe Duffy’s clinical, research, scholarly activities are primarily focused on neuropathologies of speech and language. He is the author of four editions of the textbook Motor Speech Disorders: Substrates, Differential Diagnosis, and Management. He is a Fellow in the American Speech-Language-Hearing Association (ASHA) and has been awarded the Honors of ASHA and the Frank R. Kleffner Lifetime Clinical Career Award from the American Speech-Language-Hearing Foundation.