skool 20206 02 20 Q and A LDN Support Group www.skool.com/ldnsupportgroup скачать в хорошем качестве

skool 20206 02 20 Q and A LDN Support Group www.skool.com/ldnsupportgroup

skool 20206 02 20 Q and A LDN Support Group www.skool.com/ldnsupportgroup This discussion centers on chronic pain, fibromyalgia, ME/CFS, trauma-related nervous system dysregulation, MCAS, LDN (low-dose naltrexone), ketosis, and emerging therapies such as peptides and metabolic modulators. A major theme is endorphin biology. Endorphins are peptide hormones derived from POMC (pro-opiomelanocortin) and produced in the pituitary, hypothalamus, and immune cells. Unlike neurotransmitters such as serotonin or dopamine, they are not easily manipulated by simply taking precursor amino acids. While tyrosine or 5-HTP may support broader neurochemistry, endorphin production is more complex and often impaired in chronically ill, medication-sensitive patients. LDN is described as working indirectly by temporarily blocking opioid receptors, prompting a rebound increase in endorphins. However, in depleted individuals, this rebound may fail. Escalating doses too quickly can worsen symptoms if endorphins remain blocked without adequate endogenous production. The speaker emphasizes ultra-low starting doses and very slow titration, especially in patients with post-exertional malaise (PEM) or trauma histories. Fibromyalgia is framed as potentially heterogeneous: some cases are inflammatory, others driven by central sensitization. LDN appears more effective in inflammatory subtypes, as it targets neuroinflammation. Chronic unrelieved pain (“pain without breaks”) may deplete endorphins, disrupt restorative sleep, and contribute to ME/CFS-like patterns over time. Early intervention is considered more effective, including in related conditions like CRPS. Pain Reprocessing Therapy (PRT) is discussed as helpful for centrally mediated pain. Trauma and meaning-making also play roles; a case example illustrates how unresolved religious guilt intensified symptoms until addressed through pastoral consultation. Metabolic strategies are heavily emphasized. Ketosis is described as a powerful intervention for autoimmune and inflammatory conditions. A “ketosis ladder” ranges from one meal a day to prolonged fasting. Short therapeutic fasts (e.g., three days with electrolytes) are cited as potentially reducing acute MCAS symptoms. The core “toolkit” referenced includes LDN, methylene blue, and ketosis. Diet change is acknowledged as emotionally difficult, but metabolically impactful. Metformin and berberine are compared. Berberine may alter gut flora due to antimicrobial effects. Metformin is inexpensive and accessible. Preference is expressed for ketosis as foundational metabolic therapy. Emerging or experimental topics include GLP-1 agonists, FGF-21, peptides, and bioregulators. Peptides are described as legally complex in the U.S., often marketed for research use. There is caution about unsupervised biohacking practices. Bioregulators are mentioned as an alternative approach. A participant shares an extensive medical history: facial trauma from a bicycle accident with nerve injury and tooth loss; later assault causing jaw/neck aggravation; myofascial pain and TMJ degeneration; dry mouth and dry eyes with negative rheumatologic labs; menopause; medication sensitivities; severe LDN reactions including autonomic symptoms, rash, neuropathic sensations, and disrupted sleep; significant insomnia; history of EMS work and trauma exposure; and environmental stressors including prolonged construction dust and possible mold exposure. The speaker attributes much of the symptom complex to trauma-induced immune and nervous system dysregulation, possibly MCAS and “seronegative” autoimmune phenomena (e.g., Sjögren’s with negative labs). Recommendations if local would include nervous system regulation approaches, cautious LDN reconsideration at micro-doses, endorphin rebuilding strategies, and MCAS tools such as ketotifen or methylene blue. Environmental stressors are also significant: 18 months of adjacent construction, dust exposure escalated to regulatory authorities, structural housing damage, and anticipated stress from moving. The participant fears symptom worsening due to immune strain. Administrative themes include online platform moderation, concerns about misinformation, and migration away from Facebook due to censorship risk. Overall, the discussion integrates trauma biology, immune dysregulation, metabolic therapy, endorphin physiology, cautious pharmacologic titration, and environmental contributors to chronic pain and fatigue syndromes.