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#mechanisms #drnajeeblectures #typesofshock #shock #drnajeeb Shock | Types And Mechanisms of Shock | Dr Najeeb Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 1000+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $24 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/ --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 1000+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ 0:00 Types, Mechanisms & Stages of Shock Definitions of different types of shocks; HYPOVOLEMIC SHOCK CARDIOGENIC SHOCK DISTRIBUTIVE SHOCK & its 3 types: 1-Anaphylactic Shock 2-Neurogenic Shock 3-Septic Shock 22:22 OBSTRUCTIVE SHOCK CAUSES of HYPOVOLEMIC SHOCK 1-HEMORRHAGE: External Hemorrhage Internal Hemorrhage 2-LOSS OF PLASMA: Exfoliative Dermatitis 3-LOSS OF FLUIDS & ELECTROLYTES: Diarrhea & Vomiting Polyuria: e.g., Diabetic Ketoacidosis Excessive Sweating 3rd Spacing; Ascites, Bowel Obstruction, Acute Pancreatitis, 36:20 CARDIOGENIC SHOCK 1-ARRHYTHMIAS: Tachyarrhythmia & Bradyarrhythmia 2-TRUE PUMP FAILURE: Massive Myocardial Infarction Cardiomyopathies CARDIOMYOPATHIES 3-SEVERE VALVULAR DYSFUNCTION: Valvular Regurgitation; like Mitral Valve Regurgitation, Aortic Valve Regurgitation. 4-RUPTURE OF VENTRICULAR SEPTUM or FREE WALL 53:09 DISTRIBUTIVE SHOCK: 1-Neurogenic Shock: Vasomotor Center Failure/Depression 2-Anaphylactic Shock 3-Septic Shock 1:02:35 Acute Adrenal Insufficiency 1:21:21 OBSTRUCTIVE SHOCK: 1-Cardiac Tamponade 2-Tension Pneumothorax 3-Massive Pulmonary Embolism 4-Atrial Myxoma 5-Left Atrial Mural Thrombus 1:15:20 Syncope; Vasovagal shock. Outline of STAGES OF SHOCK: 1-Non-Progressive Compensated Stage 2-Progressive Stage of Shock 3-Refractory Shock/Irreversible Shock 4-NON-PROGRESSIVE COMPENSATED STAGE SHOCK; in detail: 1-Sympathetic Autonomous Nervous System (SANS): Chemoreceptors, Baroreceptors, Vasomotor Center, Vasoconstriction & Arterioloconstriction Cardiac Output (CO) & Systolic Blood Pressure (SBP), Total Peripheral Resistance (TPR) & Diastolic Blood Pressure (DBP) Compensatory mechanisms try to stabilize the blood pressure. 2-Renin-Angiotensin-Aldosterone Axis System (RAAA): Reduced renal perfusion, Renin release, Angiotensin-1, Angiotensinogen (ATG), Angiotensin-2 (AT-2) Why more Renin is released? Arterioloconstriction leads to increased TPR; DBP stabilized. AT-2 act on Adrenal Cortex; ZG will release Aldosterone; salt & water retained; increased blood volume; SBP stabilized. 3-ADH(Vasopressin 4-REVERSE STRESS-RELAXATION of Circulatory System 5-FLUID SHIFT (Interstitial to Vascular) 1:52:07 PROGRESSIVE STAGE OF SHOCK: Compensatory Mechanisms are exhausted and are failing; deterioration starts. Fight b/w Vasoconstrictor & Vasodilator mechanisms. "Peripheral tissues will become resistant to the compensatory vasoconstrictor mechanisms & start vasodilating". Endothelial Cells are injured; NO is released which acts as Vasodilator and cardio depressant. Lactic Acidosis Disseminated Intravascular Coagulation (DIC) 2:06:45 REFRACTORY IRREVERSIBLE STAGE: "Cells & tissues start committing suicide". 1-Na+K+ ATPases are not working 2-Lysosomal Membrane breaks down 3-ATP into Adenosine; raised uric acid in the blood. 2:16:36 Post mortem findings in these patients. SEPTIC SHOCK & its types: 1-Bacteremia 2-Septicemia 3-Endotoxemia Differences b/w in Gram +ve & Gram -ve bacteria. Differences b/w Endotoxins & Exotoxins. 4-Pyemia 5-Empyema 6-Abscess --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to perks: Sign up now on our website at https://members.drnajeeblectures.com/... / @doctornajeeb Follow us on Facebook :- / drnajeeb Follow us on Instagram :- / drnajeeblectures