Antifungals: Module 4 – Echinocandins (Caspofungin, Micafungin, Anidulafungin) Conceptual overview скачать в хорошем качестве

Antifungals: Module 4 – Echinocandins (Caspofungin, Micafungin, Anidulafungin) Conceptual overview

Echinocandins don't poison the fungus; they sabotage its architecture. While they are the "safe" darlings of the ICU, using them blindly is a recipe for disaster. In this lecture, we explain why these drugs are surgical for Candida but useless for Cryptococcus and Molds, and why "starting an echinocandin" isn't a substitute for a clinical diagnosis. Part 3 of our "Antifungal Drug Classes" series focuses on the β-(1,3)-D-glucan synthase inhibitors. We move beyond basic pharmacology to discuss DM/NEET SS-level concepts: the biology of the fungal cell wall, the "Eagle Effect," and the rising threat of FKS gene mutations in the ICU. A septic ICU patient with persistent candidemia is on Micafungin. The species is identified as C. glabrata. Despite 5 days of therapy, blood cultures remain positive. Do you increase the dose, or do you look for something else? Hint: Antifungals cannot sterilize hardware. Answer in the comments. "Which Echinocandin is your 'go-to' in the ICU? (A) Caspofungin - the classic, (B) Micafungin - the reliable, or (C) Anidulafungin - the renal-friendly? Let's discuss why you chose it below." About the Channel:- Welcome to Medicine Beyond Harrison's. We provide exhaustive, high-level medical content for General Medicine graduates, MD/DNB residents, and aspirants for NEET SS (ID/Critical Care), INI-SS, and MRCP UK. We bridge the gap between textbook theory and bedside reality. Our content is synthesized from UpToDate, IDSA guidelines, and standard reference works to help you master the "Consultant Mindset." References & Standard Sources Harrison's Principles of Internal Medicine (21st Edition) - Ch. 211: Antifungal Therapy. UpToDate: "Pharmacology of Echinocandins" & "Management of Candidemia in Adults." IDSA Clinical Practice Guideline for the Management of Candidiasis. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (9th Ed). Journal of Clinical Microbiology: Review on FKS mutations and Echinocandin resistance. Echinocandins, Antifungal Drugs, Internal Medicine, Critical Care, Infectious Disease, NEET SS Medicine, MRCP Part 1, MRCP Part 2, MD Medicine, Caspofungin, Micafungin mechanism of action, Anidulafungin vs Caspofungin, Beta-glucan synthase inhibitor, FKS gene mutation Candida, Echinocandin resistance in C. glabrata, Treatment of Candidemia in ICU, Why echinocandins fail in Cryptococcus, Antifungal step-down therapy, Invasive Aspergillosis salvage therapy #InternalMedicine #CriticalCare #InfectiousDisease #Echinocandins #NEETSS #MRCP #MedEd #MedicineBeyondHarrisons #Candidemia #pharmacology