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What if consciousness isn’t just neurons firing—but quantum vibrations inside microtubules, organized by nature’s own optimization rule? In this episode, we sit down with Mike Weist, neuroscientist and experimentalist, to explore a bold synthesis: microtubules as the physical substrate of consciousness, room-temperature quantum effects in living tissue, and how active inference might actually require quantum implementations. From anesthetics and the Meyer–Overton law, to MRI hints of macroscopic entanglement, to least action and discrete “frames” of perception, this conversation reframes the mind–brain problem. We explore: 🔹 Why volatile anesthetics point beyond ion channels—toward tubulin/microtubules 🔹 Room-temperature superradiance and why quantum effects can strengthen with scale 🔹 Evidence and mechanisms for microtubule–membrane coupling (and cross-neuron coherence) 🔹 Binding problem → why classical models risk epiphenomenalism 🔹 Objective reduction (Orch-OR), discrete perceptual cycles, and memory capacity (Grover + nets) 🔹 Active Inference vs. classical neurons: why computation may need quantum substrates 💡 One of the most integrative talks at the edge of neuroscience, quantum biology, and computational mind theory. ▶ Subscribe for more deep conversations on the future of science, medicine, and intelligence. Chapters 0:00 Mind–nature symmetry & intro to Mike Weist 3:42 Is quantum consciousness going mainstream? Resistance & experiments 8:25 Microtubules 101 and the core hypothesis 14:15 Meyer–Overton: anesthetics beyond ion channels 19:50 Rat study: brain-penetrant taxane (EPOB) delays isoflurane LORR 23:18 Classical vs quantum pathways; tadpole microtubule anesthesia 32:23 Binding problem & the epiphenomenalism trap 35:50 Objective reduction and macroscopic coherence requirements 36:47 Microtubule resonances coupling with membrane voltage 39:04 Time-crystal–like hierarchies; scale-free dynamics 43:54 Room-temperature superradiance in tubulin assemblies 44:47 Sketching a “quantum optical computer” in neurons 47:44 MRI hints of macroscopic entanglement in the living brain 49:40 Community uptake, controversies, and Orch-OR misconceptions 54:46 Free Energy Principle, LLM analogies, and quantum cognition 1:01:02 Least action & path integrals as the brain’s dynamical logic 1:07:52 Can classical neurons implement active inference? 1:10:34 Discrete frames: masking, flash-lag, and gamma bursts 1:17:47 Quantum memory capacity (Grover + neural nets) 1:20:19 Final takeaways: active inference via Orch-OR Learn more at https://www.fp1.ai/ Produced by https://www.horizonsearch.co/