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In this groundbreaking TEDxUniversityofPretoria talk, Dr. Kgomotso Mathabe — a urologist, lecturer, and researcher — challenges long-standing assumptions about how cancer spreads. Through the compelling story of a prostate cancer patient, she reveals a possible fifth route of metastasis: one that travels along the nerves — a pathway doctors may have been overlooking for decades. By connecting science, compassion, and innovation, Dr. Mathabe calls on the global medical and research community to pause, re-examine what they see, and explore this potential new lens — neurogenous metastasis. This talk is a powerful reminder that even in a world guided by science and data, true progress often begins when we dare to question what we think we already know. #TEDxUniversityofPretoria #CancerResearch #MedicalInnovation #Neuroscience #Healthcare Kgomotso Mathabe is the head of the Department of Urology at the University of Pretoria and Steve Biko Academic Hospital, where she oversees clinical services, teaches undergraduate medical students, and trains medical specialists, including research supervision. She was the first woman to qualify as a Urologist at the University of the Witwatersrand and the second Black woman in the country. She holds qualifications in medicine including specialisation in Urology and healthcare management, and outside of medicine in gifted education, public management, and governance. Kgomotso believes a healthy, educated, and skilled nation can solve its own problems and co-create solutions with government, reducing dependence. Thus, education, skills development, and health services should be prioritised. She also values continuous personal development and lifelong upskilling. She is currently a PhD candidate studying the interaction of prostate cancer with the nervous system. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx