Actinic Cheilitis | Dentistry скачать в хорошем качестве

Actinic Cheilitis | Dentistry

Learn all about actinic cheilitis diagnosis and actinic cheilitis histopathology. Medical student study of an important ENT disease just became easy. ▬ 📌 Actinic Cheilitis Risk Factors 👉 Risk factors contribute to the disease process 🟢 Middle aged to elderly 🟢 Men: Women (10:1) 🟢 Fair complexion 🟢 Outdoor occupation: farmers, construction workers, lifeguards, and sailors 🟢 Albinism 🟢 Immunosuppression: malignant cells are not recognized and destroyed at an early stage 🟢 Tobacco smoking: alterations in the epithelial cells ▬ 📌 Actinic Cheilitis Clinical Features Actinic cheilitis develops slowly over years, so it may go unnoticed for years. ✔️ Atrophy, dryness, and fissures on the lower lips Due to the atrophy of the surface epithelium the area becomes smooth blotchy and slightly pale ✔️ Blurring of the margin between the vermillion and skin ✔️ Rough scaly area develops as the lesion progresses ✔️ May also thicken to form Leukoplakia ✔️ Chronic Ulcerations develop, which may last for months ✔️ After some years ulcerations progress to malignancy ▬ 📌 Pathogenesis UVA and UVB from the sun, causes ionization in cells, this releases Hydroxyl and oxygen radicals which lead to DNA damage. ✔️ Mutation occurs in the P53 Tumor suppression gene ✔️ Normal cell cycle is interrupted ✔️ Genetic alteration of the epithelial cells ✔️ Uncontrolled cell proliferation. Watch the video to understand the pathogenesis in more detail ▬ 📌 Histopathological Features 👉 Mild to Moderate dysplasia ⚫️ Increased Nuclear: Cytoplasmic ratio ⚫️ Hyperchromatic nuclei ⚫️ Increased mitotic activity ⚫️ Loss of rete ridges ⚫️ Acanthosis of the epithelium ⚫️ Hyperkeratotic or Atrophic Keratin Layer ▬ 📌 Actinic Cheilitis Treatment Photoprotection, to prevent further damage. ✔️ Reduce sun exposure ✔️ Wide brimmed hat ✔️ Use sunscreen 👉 Vermilionectomy 🟣 The vermillion mucosa is surgically excised. 🟣 The intraoral mucosa may be pulled forward or it may be allowed to heal by secondary intention Watch the video above to learn some of the adverse effects associated with this procedure. 👉 Laser ablation 🟠 CO2 or Erbium: YAG laser may be used to excise the lesion. 🟠 Adverse effects: Pain and Hypertrophic scarring 👉 Phototherapy ✔️ Light therapy at an increased intensity may release reactive oxygen species to destroy damaged skin cells. ✔️ Very high chances for the lesion to re-occur with this choice of treatment. 👉 Cryotherapy 🟡 Cold temperatures are used to destroy damaged cells. 🟡 Adverse effects: Pain, crusting scarring and reduced efficacy is associated. 👉 Topical Treatment 🟠 5 fluorouracil 🟠 Imiquimod 🟠 Pain crusting and inflammation are some if the adverse effects. This was all about brief overview of Actinic Cheilitis. ▬ 🎬 5500+ sqadia.com Medical Videos ▬▬▬▬▬▬▬▬▬▬ 👩🏻‍⚕️ Accessible Medical Student Education 24/7/365 💡 Simplifying Medical Learning 💪 Study Hard, Dream Big, Achieve More