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Watch the Full Video at https://www.jove.com/v/57270/stereota.... Stereotaxic Surgery for Genetic Manipulation in Striatal Cells of Neonatal Mouse Brains - a 2 minute Preview of the Experimental Protocol Shih-Yun Chen, Hsiao-Ying Kuo, Fu-Chin Liu National Yang-Ming University, Institute of Neuroscience; National Yang-Ming University, Brain Research Center; We describe a protocol of stereotaxic surgery with a homemade head-fixed device for microinjecting reagents into the striatum of neonatal mouse brains. This technique allows genetic manipulation in neuronal cells of specific regions of neonatal mouse brains. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments