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• Is food restriction the cause of weight lo... Roux En Y Gastric Bypass Part 2 - Why is weight loss long lasting after 'Roux En Y Gastric Bypass' while lifestyle modifications fail in long run? - Dr. Amar Vennapusa, +91 9676675646 In roux y gastric bypass, a small gastric pouch is created. Jejunum (Second part of small intestine) is divided and connected to the gastric pouch. In short, we are creating a short cut between stomach pouch and small intestine. Because of gastric pouch there is food restriction. Since part of the small intestine is bypassed, there is malabsorption. But the main causes of weight loss or diabetes remission are not food restriction or malabsorption, these are due to physiological and genetic changes. Because of rapid emptying of stomach, undigested food reaches end of small intestine faster leading to increased hunger suppressing hormones, GLP1 and Peptide YY. Bypassing part of small intestine reduces anti incretins, further reducing fat set point. GLP1 and Peptide YY increase insulin production and reduce insulin resistance. So blood sugars are normalised. Like this there are more than 200 hormonal changes and more than 5000 genetic changes. Fat set point is reset to a lower level leading to long lasting weight loss. Insulin production increases and insulin resistance comes down leading to long term diabetes remission. For regular updates on bariatric and metabolic surgeries and healthy life style, please subscribe to my youtube channel @drVamar and follow my instagram page @drVamar - Dr. AMAR VENNAPUSA Chief Consultant Bariatric & Metabolic Surgeon Dr. Amar Bariatric & Metabolic Center 🌏 www.drvamar.com 📱+91 9676675646 📨 [email protected]