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The goal of the video is to minimize any potential source of stress while blood sampling from the lateral vein of the rat. Watch the full video at https://www.jove.com/v/52766/sampling..., no sign up needed for open access content, or request a trial to get instant access to our full library. It reduces the influence of acute stress response on the composition of the blood which eventually decreases the value of CORT level depicting that this method does not represent a significant source of stress during blood collection. Visit https://www.jove.com/?utm_source=yout... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard and the University of Cambridge, benefit from using JoVE’s extensive library of 14000 videos in their research and teaching. Follow JoVE on Twitter: / jovejournal Like JoVE on Facebook: / jovejournal Subscribe to our channel: / jovejournalofvisualizedexperiments