Pharmacology of Hydrocodone ; Mechanism of action, Pharmacokinetics, Uses, Effects скачать в хорошем качестве

Pharmacology of Hydrocodone ; Mechanism of action, Pharmacokinetics, Uses, Effects

Hydrocodone is a synthetic opioid used primarily for pain management and as a cough suppressant. Here are some key points about its pharmacology: Mechanism of Action: Hydrocodone is a μ-opioid receptor agonist, meaning it binds to and activates the μ-opioid receptors in the central nervous system, providing pain relief. Formulations: It is commonly available in combination with acetaminophen (e.g., Vicodin, Norco) or ibuprofen (e.g., Ibudone) for pain relief, and with homatropine or guaifenesin for cough suppression. Dosage: The dosage varies depending on the indication and patient's condition. For pain, it is typically 5-10 mg every 4-6 hours as needed. For cough, the dosage is usually lower1. Metabolism: Hydrocodone is metabolized in the liver by CYP3A4 and CYP2D6 enzymes. Its primary active metabolite is hydromorphone, which contributes to its analgesic effects. Adverse Effects: Common side effects include dizziness, drowsiness, nausea, vomiting, constipation, and pruritus (itching). Serious side effects can include respiratory depression, low blood pressure, seizures, and serotonin syndrome. Clinical Uses: Hydrocodone is indicated for the management of moderate to severe pain and as a cough suppressant1. It is classified as a Schedule II controlled substance in the United States due to its potential for abuse and dependence #Hydrocodone