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Watch the Full Video at https://www.jove.com/v/2422/a-protoco.... A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS) - a 2 minute Preview of the Experimental Protocol Yana Yunusova, Jordan R. Green, Jun Wang, Gary Pattee, Lorne Zinman University of Toronto, Department of Speech-Language Pathology; Sunnybrook Health Science Centre, ALS/ MN Clinic; University of Nebraska-Lincoln, Department of Special Education and Communication Disorders; University of Nebraska Medical Center, Department of Neurology, Munroe-Meyer Institute; University of Toronto, Department of Neurology; Objective assessments of the physiological mechanisms that support speech are needed to monitor disease onset and progression in persons with ALS and to quantify treatment effects in clinical trials. In this video, we present a comprehensive, instrumentation-based protocol for quantifying speech motor performance in clinical populations. Visit https://www.jove.com?utm_source=youtu... to explore our entire library of 14,000+ videos of laboratory methods and science concepts. JoVE is the world-leading producer and provider of science videos with the mission to improve scientific research and education. Millions of scientists, educators, and students at 1500+ institutions worldwide, including schools like Harvard, MIT and Stanford benefit from using JoVE's extensive library of 14,000+ videos in their research,education and teaching. Subscribe to our channel: / jovejournalofvisualizedexperiments