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Mediastinal lymphadenectomy is a surgical procedure performed to remove lymph nodes in the mediastinal region of the chest. The mediastinum is the central compartment of the chest that contains vital structures such as the heart, great vessels, trachea, esophagus, and lymph nodes. Lymphadenectomy refers to the removal of lymph nodes to assess for the presence of cancer, stage the disease, or provide therapeutic benefits. The procedure is commonly performed as part of the surgical treatment for lung cancer, particularly non-small cell lung cancer. Mediastinal lymph nodes are frequently involved in lung cancer metastasis, and their evaluation is crucial for accurate staging and determining the appropriate treatment plan. By removing and examining the lymph nodes, surgeons can determine the extent of cancer spread and make informed decisions regarding further treatment options. Mediastinal lymphadenectomy is typically performed as part of a larger surgical procedure called thoracic surgery or thoracotomy. During the procedure, an incision is made in the chest wall to access the mediastinum. The surgeon carefully dissects and removes the lymph nodes in the region using specialized instruments. The exact extent of lymph node dissection depends on the specific surgical approach and the location of the tumor. The removed lymph nodes are then sent to the pathology laboratory for microscopic examination. Pathologists evaluate the lymph nodes for the presence of cancer cells, assess the extent of involvement, and determine the stage of the disease. This information is crucial for oncologists in planning further treatments, such as chemotherapy, radiation therapy, or targeted therapies. Mediastinal lymphadenectomy is a complex surgical procedure that requires the expertise of thoracic surgeons. It carries certain risks and potential complications, including bleeding, infection, damage to nearby structures such as blood vessels or nerves, and postoperative complications like lymphedema or seromas. The decision to perform mediastinal lymphadenectomy is based on various factors, including the type and stage of the cancer, patient's overall health, and the surgeon's judgment. It is typically reserved for cases where there is a significant risk of lymph node involvement or when accurate staging is crucial for treatment planning.