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Endothelial cells form a protective inner layer around every blood vessel in the body, including in the brain where they help to form the blood-brain barrier (BBB). Without these cells, our blood vessels would not work properly. They also promote healthy blood flow by releasing nitric oxide which controls the dilation of blood vessels so they can provide more nutrients to the brain where it is needed. In the BBB, the endothelial cells fuse together and form junctions to ‘plug’ the gaps which would otherwise allow anything in the blood to enter the brain. This selective barrier protects the brain from many drugs or toxins. Studies of brain injury related to preterm birth have shown that an immature vasculature may predispose infants to bleeding in the brain and impaired transfer of nutrients from the blood to the brain across the blood vessels. #cells #cellbiology #braincells PREMSTEM has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 874721. Results reflect the author’s view only. The European Commission is not responsible for any use that may be made of the information it contains. Visit the PREMSTEM website to learn more about our research project and download our fact sheets: https://www.premstem.eu/