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PGC-1α

PGC-1α (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha) is a protein that plays a crucial role in regulating mitochondrial biogenesis, metabolism, and cellular energy production. It is a transcriptional coactivator that works with other proteins to control the expression of genes involved in energy metabolism, mitochondrial function, and oxidative stress resistance. PGC-1α is induced by physical activity, exercise, and environmental stimuli, and it has been implicated in various physiological processes, including: 1. Mitochondrial biogenesis and function 2. Glucose and lipid metabolism 3. Insulin sensitivity and glucose uptake 4. Cellular stress resistance and antioxidant defenses 5. Inflammation and immune response 6. Neuroprotection and neuroplasticity PGC-1α has been studied extensively in the context of exercise and physical activity, where it is thought to play a key role in the adaptive responses to muscle contraction and stress. It has also been implicated in various diseases, including: 1. Metabolic disorders (e.g., diabetes, obesity) 2. Neurodegenerative diseases (e.g., Alzheimer's, Parkinson's) 3. Cancer 4. Cardiovascular disease Overall, PGC-1α is an important regulator of cellular metabolism and energy production, and its dysregulation can contribute to various diseases and disorders. Muhammad umer farooq, i am making biology videos behaviour, plant science and biomedical science videos.i am graduated from pakistan university of veterinary and animal sciences lahore.this is my own official channel Muhammad umer farooq biology. please join Created lecture:Muhammad umer farooq Edit:Muhammad umer farooq biology Voice over:Muhammad umer farooq biology Design:Muhammad umer farooq biology Research By:Muhammad umer farooq biology #muhammadumerfarooqbiology #pgc1alpha #mitochondria ‪@umerfarooqbiology7083‬