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Discover how PET-adapted treatment strategies are transforming the management of advanced-stage classical Hodgkin lymphoma (cHL). This video explores the evolution of treatment paradigms, from traditional chemotherapy regimens like ABVD and BEACOPP to modern, personalized approaches guided by interim PET scans. Learn how early response assessment with PET2 is reshaping treatment de-escalation and escalation, minimizing toxicity while maximizing efficacy. We delve into key clinical trials such as RATHL, AHL2011, and HD18, highlighting their impact on progression-free survival (PFS) and overall survival (OS). Additionally, we discuss emerging therapies like brentuximab vedotin (BV) and immune checkpoint inhibitors, which are setting new standards in first-line treatment. Whether you're a healthcare professional, patient, or caregiver, this video provides a comprehensive overview of the latest advancements in cHL treatment, emphasizing the importance of individualized care in the PET-adapted era.