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In this 9-minute presentation, Wayne Brisbane, MD, explores the integration of AI in focal therapy for prostate cancer management at UCLA. Dr. Brisbane begins by outlining the historical overtreatment of prostate cancer and the evolving efforts to refine management through advanced imaging modalities and AI-based tools. He highlights the role of Unfold AI, a system designed to estimate tumor margins and volumes using multiparametric MRI, biopsy data, and patient demographics. Multifocal disease and margin estimation challenge focal therapy. Dr. Brisbane explains how AI helps address this by creating detailed cancer estimation maps. He presents data showing the correlation between AI-predicted tumor volumes and clinical outcomes. Clinical examples underscore the AI’s ability to improve margin estimation, identify residual disease risks, and refine patient selection. A comparison of AI-based predictions with observed surgical margins confirms its reliability, outperforming traditional metrics like grade groups and PSA density. Dr. Brisbane also discusses the utility of Unfold AI in identifying patients with extra-capsular extension who might otherwise be unsuitable for focal therapy. Don't forget to join the GRU Community: https://grandroundsinurology.com/regi... Follow us on Twitter/X: https://x.com/GRUrology And like and subscribe to us here on YouTube!