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Chorionic villus sampling (CVS) is a prenatal test in which a sample of chorionic villi is removed from the placenta for testing. Chorionic villus sampling is usually done between weeks 10 and 13 of pregnancy Chorionic villus sampling can provide information about your baby's genetic makeup You might consider chorionic villus sampling if: You had a chromosomal condition in a previous pregnancy. If a previous pregnancy was affected by Down syndrome or another chromosomal condition, this pregnancy is at higher risk, too. You're 35 or older. Babies born to women 35 and older have a higher risk of chromosomal conditions, such as Down syndrome. You have a family history of a specific genetic condition, or you or your partner is a known carrier of a genetic condition. In addition to identifying Down syndrome, chorionic villus sampling can be used to diagnose many other genetic conditions — including single gene disorders such as Tay-Sachs and cystic fibrosis