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CANNABINOID DISSOLUTION RESULTS

The pharmacokinetic performance of the patented VESIsorb® delivery system is consistent and predictable. Pharmacological approaches to predicting efficacy traditionally start with measuring dissolution. It is widely accepted in the pharmaceutical and nutraceutical industries that high dissolution correlates to optimal absorption of oral dosages. It is clear that this is not necessarily always the case, but it is consistently measured and used as a starting point in the analysis of drugs and in many cases nutraceuticals. Geocann follows this protocol and has dissolution results for all approved VESIsorb® formulations. Our experience has supported the premise that once we successfully developed a VESIsorb® formulation the resulting colloidal droplets keep the active ingredient in a solubilized form within an aqueous environment over time. Dissolution experiments show consistent results close to 100% solubilized active. We have also measured competitive formulations of coenzyme Q10 for example and found extremely poor dissolution. Additionally we have collaborated with other researchers and labs and found similarly disappointing dissolution results testing competitive products. These disappointing dissolution results from other companies correlate consistently with poor PK results.