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Dr. Mario Castro (Washington University School of Medicine) presents findings from the Severe Asthma Research Program (SARP), providing insights into severe asthma disease phenotypes and approaches for targeted therapy. Dr. Castro highlights the use of imaging technologies to better understand the lung changes that occur in severe asthma. His findings identify subgroups of patients with specific changes in the lung. The hope is that identification of these subgroups will inform the use of targeted therapies. Dr. Castro also presents data on the effects of dupilumab treatment. Dupilumab is a monoclonal antibody that targets IL-4 receptor alpha (anti-IL-4R). Recent clinical trials published in the New England Journal of Medicine showed that dupilumab treatment improves patient outcomes. This webinar was hosted by the NHMRC Centre of Excellence in Severe Asthma on 19 June 2018. Dr. Castro's travel was supported by funding from AstraZeneca.