4-Key Signaling Pathways in Fibrosis скачать в хорошем качестве

4-Key Signaling Pathways in Fibrosis

In this video, Dr. Far explores the key signaling pathways that activate and sustain fibrosis. Building on the previous episode about the main fibrotic cells, this video focuses on six major pathways: TGF-β/SMAD, Wnt/β-catenin, Hippo–YAP, Notch, Hedgehog,** and **cytokine crosstalk. Dr. Far explains how TGF-β, the master regulator of fibrosis, activates SMAD proteins to drive pro-fibrotic genes and works with MAPK and PI3K/AKT pathways to reinforce fibroblast activation. Wnt/β-catenin acts in synergy with TGF-β, promoting fibrotic gene expression across organs. The Hippo–YAP pathway links mechanical stiffness to fibrosis, as YAP and TAZ sense matrix rigidity and perpetuate myofibroblast activation. Notch and Hedgehog further regulate fibroblast proliferation and immune interactions, while cytokines like PDGF, IL-13, and IL-4 amplify fibroblast activity through feedback signaling. References: • Deng Z, et al. TGF-β signaling in health, disease and therapeutics. Signal Transduct Target Ther. 2024. https://pubmed.ncbi.nlm.nih.gov/38514... • Somanader DVN, et al. Wnt/β-catenin in fibrosis (review). 2024. https://pubmed.ncbi.nlm.nih.gov/38490... • Cai X, et al. Mechanoregulation of YAP/TAZ — review. Front Cell Dev Biol. 2021. https://www.frontiersin.org/journals/... • Zhang X, et al. Notch signaling regulates pulmonary fibrosis. Front Cell Dev Biol. 2024. https://www.frontiersin.org/journals/... • Hu Y, et al. Hedgehog signaling in fibrosis and targeted therapy. Biomolecules/MDPI. 2024. https://doi.org/10.3390/biom14121485 • Di X, et al. Crosstalk between fibroblasts and immunocytes in fibrosis. Clin Transl Med. 2024. https://pubmed.ncbi.nlm.nih.gov/38264... #fibrosis #TGF-β #science #smad #wnt #bcatenin #mapk #pi3k/akt #hippo #yap #taz #pdgf #interlukin-13