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UHMS 14 Thermal Burns

#HyperbaricOxygen #BurnCare #ThermalBurns #HBO #WoundHealing #BurnTreatment #HBOTherapy #UHMS #DeepDive #BurnInjury Thermal burn injury is a complex, devastating trauma with significant morbidity, mortality, and cost. Adjunctive hyperbaric oxygen therapy (HBO) treatment, as detailed in a comprehensive review chapter, presents evidence from decades of animal and human studies exploring its potential to improve outcomes. Experimental data consistently shows benefits including edema reduction, preservation of microcirculation and tissue viability, enhanced healing, and improved survival. Proposed mechanisms involve modulating inflammation, reducing microcirculatory obstruction, influencing ischemia reperfusion injury, enhancing host defenses, reducing bacterial translocation, and mobilizing stem cells. Clinical experience reports improved healing, decreased length of hospital stay, reduced mortality in larger series, decreased surgeries, lower fluid requirements, and cost savings. Despite debates on evidence synthesis, the source strongly advocates for considering HBO in serious burns, especially those involving functional areas (20% TBSA+ or hands, face, feet, perineum), administered early (2.0-2.4 ATA) by trained staff, citing compelling data supporting its multifaceted benefits on burn pathophysiology.