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Mastocytosis Visually Explained

Mastocytosis overview including pathogenesis, clinical features, diagnosis, and management with mnemonics for medical students and nursing students. Discussion of Stem Cell Factor, KIT, and Darier’s Sign. and other extra-articular features associated with the condition and Crohn’s disease or Ulcerative colitis. Novel memory tricks at the end! With a breakdown of the classification of mastocytosis - Cutaneous mastocytosis is commonly diagnosed in young children and disease is limited to the skin with an absence of pathologic infiltrates in internal organs. There are 3 variants of the cutaneous disease: 1. Maculopapular cutaneous mastocytosis 2. Diffuse cutaneous mastocytosis 3. Solitary mastocytoma Systemic forms of the disease mostly affect adults and can infiltrate organs. There are 5 variants of this version which can be indolent or aggressive: 1. Indolent systemic mastocytosis (ISM) 2. Smoldering systemic mastocytosis 3. Systemic mastocytosis with an associated clonal hematologic non–mast cell lineage disease (SM-AHNMD) 4. Aggressive systemic mastocytosis (ASM) 5. Mast cell leukemia (MCL) 0:00 Introduction 0:21 Physiology 0:52 Pathogenesis 1:30 Classification 2:08 Clinical Features 3:53 Investigations 4:32 Management 5:14 Mnemonic Disclaimer: This video was intended for educational purposes only and not to be considered medical advice. All information was sourced from a combination of reputable sources including BMJ Best Practice, ETG (Australia), UpToDate, and Harrison’s Principles of Internal Medicine. #medicalmnemonics #medicalstudents #nursingstudents #highyield