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Editor’s Summary by Linda Brubaker, MD, and Preeti Malani, MD, MSJ, Deputy Editors of JAMA, the Journal of the American Medical Association, for articles published from August 30-September 5, 2025. 00:00 Intro Research 05:50 JAMA at ESC 01:29 Bivalent RSV Prefusion F Protein–Based Vaccine for Preventing Cardiovascular Hospitalizations in Older Adults 02:02 RSV Vaccine Effectiveness Against Hospitalization Among US Adults Aged 60 Years or Older During 2 Seasons 02:51 Related Editorial: Shot Through the Heart—Can RSV Vaccination Reduce Risk of Cardiovascular Outcomes? 03:12 Semaglutide and Tirzepatide in Patients With Heart Failure With Preserved Ejection Fraction 04:46 Long-Term Anticoagulation Discontinuation After Catheter Ablation for Atrial Fibrillation 05:25 Related Editorial: Lifelong Anticoagulation After AF Ablation—Time to Reconsider? 05:58 Fractional Flow Reserve–Guided Complete vs Culprit-Only Revascularization in Non–ST-Elevation Myocardial Infarction and Multivessel Disease 06:13 Helicobacter pylori Screening After Acute Myocardial Infarction 06:36 Reporting of Clinical Trial Uncertainties With New Cancer Drugs in Journal Publications and Clinical Guidelines Viewpoints 07:44 The One Big Beautiful Bill Act—Implications for Rural Health Care 07:51 Rural Hospitals Deserve More Than Patchwork Policies 08:05 Federal Funding Conditions Threaten Gender-Affirming Care Access and Physician Autonomy Opinion 08:22 Women’s Health Is Everywhere—Introducing JAMA+ Women’s Health 08:57 Video: Introducing JAMA+ Women’s Health JAMA+AI 09:37 The Promise and Challenge of AI for Women’s Health Clinical Reviews and Education 10:59 Transparent Reporting of Observational Studies Emulating a Target Trial—The TARGET Statement 11:20 Hypothyroidism 11:40 Podcast: Diagnosis and Management of Hypothyroidism 12:11 Methamphetamine Use Disorder 12:29 Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder 12:49 Related Editorial: Are Psychedelic Agents Ready for Prime Time as Stand-Alone Treatments? 12:59 What Is Paternal Perinatal Depression? Medical News http://jamamedicalnews.com?utm_campai... Videos Mentioned: • Introducing JAMA+ Women’s Health Podcasts Mentioned: JAMA Editors Summary • From ESC: Remote Monitoring for Atrial Fib... JAMA Clinical Reviews • Diagnosis and Management of Hypothyroidism JAMA+ AI Conversations • AI in Women's Health Links to articles mentioned in this podcast can be found at https://jamanetwork.com/journals/jama... Podcast was originally published on September 5, 2025. https://edhub.ama-assn.org/jn-learnin... --------------------------------------------------------------------------------- Follow JAMA Editors' Summary on: Youtube: • JAMA Editors' Summary Apple Podcasts: https://podcasts.apple.com/us/podcast... Spotify: https://open.spotify.com/show/2yLr9YO... Pocket Casts: https://pca.st/6cbE Your podcast app of choice: https://pod.link/128978076 Website: https://jamanetwork.com/journals/jama... --------------------------------------------------------------------------------- For more from JAMA • https://www.jama.com • / jamajournal • / jama_current • / jamanetwork Follow the JAMA Network • https://www.jamanetwork.com • http://www.jamanetworkaudio.com • / jamanetwork • / jamanetwork • / jamanetwork • / jamanetwork