Dr. Benjamin Miller - "Fluorescent nanodiamonds for rapid, sensitive, low-cost diagnostics" скачать в хорошем качестве

Dr. Benjamin Miller - "Fluorescent nanodiamonds for rapid, sensitive, low-cost diagnostics"

"Fluorescent nanodiamonds for rapid, sensitive, low-cost diagnostics" by Dr. Benjamin Miller The ongoing COVID-19 pandemic has emphasized the need for sensitive, early diagnosis of infectious diseases, crucial for reducing the impact of outbreaks. Nanoparticle-based rapid diagnostics, such as lateral flow tests, are widely used for antibody detection but often lack the sensitivity required for early detection of antigen or nucleic acid targets. Fluorescent labels have been investigated as a replacement for gold nanoparticles, which are widely used on lateral flow tests, but their sensitivity is limited by the background autofluorescence of the membrane or sample. This presentation discusses recently published work from our lab incorporating fluorescent nanodiamonds into lateral flow tests with the aim of improving sensitivity. In addition to their attractive properties for in vitro biosensing, including brightness and low cost, fluorescent nanodiamonds allow for selective manipulation of their emission with an external electromagnetic field. This allows their emission to be specifically modulated at a fixed frequency and separated from background autofluorescence in the frequency domain. Although significant challenges remain in translating this proof-of-concept to a field-ready diagnostic, this work demonstrates the additional sensitivity nanodiamonds could offer in numerous diagnostic test formats, assays and diseases, with the potential to improve early diagnosis of diseases, benefiting patients and populations. Miller, B.S., Bezinge, L., Gliddon, H.D. et al. Spin-enhanced nanodiamond biosensing for ultrasensitive diagnostics. Nature 587, 588-593 (2020). https://doi.org/10.1038/s41586-020-29... Check out our website - https://www.adamasnano.com/ Find us on other socials:   / adamas-nanotechnologies-inc   https://x.com/AdamasNano