Renin Angiotensin Aldosterone System | RAAS👨‍⚕️ скачать в хорошем качестве

Renin Angiotensin Aldosterone System | RAAS👨‍⚕️

#Renin #AldosteroneSystem #DrNajeeb Renin Angiotensin Aldosterone System | RAAS👨‍⚕️ Like this video? Sign up now on our website at https://www.DrNajeebLectures.com to access 800+ Exclusive videos on Basic Medical Sciences & Clinical Medicine. These are premium videos (NOT FROM YOUTUBE). All these videos come with English subtitles & download options. Sign up now! Get Lifetime Access for a one-time payment of $24 ONLY! Sign up now on our website at https://members.drnajeeblectures.com/... --------------------------------------------------------------------------------------------------------------------------- Why sign up for premium membership? Here's why! Membership Features for premium website members. 1. More than 800+ Medical Lectures. 2. Basic Medical Sciences & Clinical Medicine. 3. Mobile-friendly interface with android and iOS apps. 4. English subtitles and new videos every week. 5. Download option for offline video playback. 6. Fanatic customer support and that's 24/7. 7. Fast video playback option to learn faster. 8. Trusted by over 2M+ students in 190 countries. --------------------------------------------------------------------------------------------------------------------------- ▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬ 00:00:00 Explanation of RAAS with the help of a case of haemorrhage 00:03:42 Renin production in detail 00:13:53 Low Renal Perfusion leads to low Glomerular Filtration 00:17:05 External or Systemic Mechanism of Renin Production 00:22:02 Function of Renin 00:31:30 Actions of Angiotensin II 00:39:34 Action of Aldosterone 00:46:19 Angiotensin II action in CNS 00:53:21 Pathological functions of RAAS --------------------------------------------------------------------------------------------------------------------------- Explaining RAAS with the help of a case of hemorrhage; Low Renal Perfusion leading to Renin release from kidney. Renin production in detail; Low blood flow in Afferent arterioles; Polkissen are the modified afferent arteriolar smooth muscles that are able to measure blood flow to nephrons. Low blood flow to nephrons; Polkissen releases Renin into the blood. Second mechanism of Renin production: Na-sensing device in DCT; Macula Densa. Polkissen measures blood flow/pressure and is derived from afferent arterioles; while Macula Densa is a Na-measuring device derived from nephrons in the kidney. Polkissen and Macula Densa are held together by connective tissues; as a complex; known as Juxta Glomerular Apparatus (JGA). Low Renal Perfusion leads to low Glomerular Filtration; slow movement of filtrate through nephrons; leads to increased Na+ reabsorption and ultimately decreased amount of Na+ reaching the Macula Densa of JG apparatus. Polkissen of JG apparatus receive that message; and increases production of Renin. Both are Intrarenal Mechanisms of Renin Production. Extrarenal or Systemic Mechanism of Renin Production: Baroreceptors in Carotid Sinus; Low blood flow activates them; message to CNS; Vasomotor Center (in Medulla) activated; stimulates the Sympathetic Outflow. Sympathetic fibers in JG apparatus release Norepinephrine (NE) to act on Beta1-adrenergic receptors in JG apparatus; leading to increased production of Renin by JG apparatus. Function of Renin: will go into systemic circulation through the renal vein. Angiotensinogen (ATG); produced by the liver. Renin; (which is an enzyme) will act on ATG and convert ATG into Angiotensin-1(AT-1). AT-1 gets converted into AT-2; enzyme in the lung (on the surface of endothelial cells) responsible for this conversion = Angiotensin Converting Enzyme (ACE). ACE inhibitors (Captopril, Enalapril). Bradykinin (a vasoconstrictor); is also broken down/inactivated by ACE; thus, doubly ensuring vasodilation. Recap. Actions of AT-2: AT-2 receptors are present in venous smooth muscles; AT-2 acts on them to cause venoconstriction; which increases Venous Return; increased Stroke Volume; increased Cardiac Output; increase in Systolic Blood Pressure (SBP). AT-2 will also cause arteriolar vasoconstriction; results in blood retained in arterial tree during diastole; increased blood pressure during diastole = Increased Diastolic Blood Pressure (DBP). AT-2’s action on Zona Glomerulosa (ZG) in Adrenal Cortex; releases Aldosterone. --------------------------------------------------------------------------------------------------------------------------- Join this channel to get access to perks: Sign up now on our website at https://members.drnajeeblectures.com/...    / @doctornajeeb   Follow us on Facebook :-   / drnajeeb   Follow us on Instagram :-   / drnajeeblectures