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Peter F. Orio III, DO, MS, Chair of Radiation Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, focuses on the management of localized prostate cancer, particularly emphasizing the use of rectal spacers to reduce radiation toxicity. In this 14-minute presentation, Dr. Orio discusses rectal spacing as a pivotal advancement in radiation oncology, enhancing the safety and efficacy of treatments by physically distancing the rectum from the prostate to minimize exposure. Dr. Orio explores various rectal spacing techniques, including SpaceOAR, Barrigel, and BioProtect. The presentation stresses the importance of precise placement and the role of imaging, particularly MRI, in enhancing treatment accuracy and reducing complications. The variability in implant symmetry across products highlights the need to carefully select and use these technologies to avoid adverse effects. The discussion concludes with considerations for extending the application of these technologies to other modalities, such as cryotherapy and focal laser ablation, reinforcing the broader implications of tumor spacing in oncologic treatment.