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Given the current landscape in liver transplantation, with a shift from younger donors to more older, obese, and DCD donors as the sources for human grafts, dynamic organ perfusion preservation strategies have become a priority in this field. In this first Bridge to Life supported Webinar, experts will discuss the basic science behind the different strategies for liver perfusion preservation and how these strategies may be used to recover, evaluate, and even improve the quality of livers for transplantation. Objectives: Understand the basic necessities for both hypothermic and normothermic machine perfusion and the potential benefits and pitfalls associated with each modality, including how each may be used to assess liver viability prior to transplantation. Agenda: Overview on Mechanism of Action and Effects of Hypothermic (Oxygenated) Liver Perfusion (James V. Guarrera) Overview on Mechanism of Action and Effects of Normothermic Perfusion in Liver Transplantation (Peter Friend) Liver Viability Assessment during Machine Perfusion (Andrea Schlegel) Panel Discussion