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Blood groups differ by their ABO and RhD markers, which determine who can safely receive red cells, plasma, and platelets. O+ is very common, can be given to all Rh-positive patients in emergencies, and is linked with slightly lower risks of severe malaria and some blood clots. A+ is also common, can receive from A and O types, and the A marker gives some protection against severe stomach infections. B+ is less common than O+ and A+ but, together with O+ stocks, usually allows quick treatment; it is more frequent in parts of Asia and the Middle East. AB+ can receive red cells from any ABO and Rh type and provides plasma and platelets that fit many patients, which is valuable in heavy bleeding and burns. O− red cells are the universal emergency choice, especially vital for newborns and for girls and women who must avoid forming anti-D antibodies. A− can be given to A and AB patients who are Rh− or Rh+, so it is a key backup for people who must stay Rh-negative. B− is rare but flexible because it can go to B and AB patients without RhD, so hospitals reserve it for trauma, surgery, and birth care. AB− is extremely rare, provides almost universally compatible plasma and very useful platelets, and is saved for the toughest matching cases. Non-O groups (A, B, AB) usually have slightly higher levels of some clotting proteins, which helps stop bleeding faster but may raise clot risk a bit over a lifetime.