Mouse tail hanging weight loss simulation instrument скачать в хорошем качестве

Mouse tail hanging weight loss simulation instrument

The rodent rat tail-sling weightless model experimental chamber is suitable for animal models often needed in aerospace medical research. It is a device for observing the adaptive changes of the cardiovascular system, skeletal muscle system, nervous system and other animals under simulated weightlessness on the ground. The mouse tail suspension model (hindlimb unloading model) is a classic experimental method to simulate physiological changes in microgravity or weightlessness environments. The principle is based on taking the hind limbs of mice out of the weight-bearing state through tail suspension, simulating the effects of skeletal muscle disuse atrophy, bone loss and cardiovascular dysfunction caused by weightlessness. Experimental method: The tail of the mouse was fixed on a special bracket, and the body was kept at a 30° tilt angle with the ground. The forelimbs could move freely and bear part of the body weight, and the hind limbs were completely suspended in the air. The experimental period is usually 2-4 weeks, during which the mice need to ensure normal diet and activities. By adjusting the suspension angle and period, the degree of mechanical load removal can be controlled. Test indicators and significance: Muscle atrophy: By measuring the wet weight, muscle fiber cross-sectional area, and myosin heavy chain expression of hindlimb muscles (such as soleus), protein degradation and muscle function decline caused by weight loss are evaluated. Bone loss: Micro-CT detects femur/tibia bone density (BMD), bone trabecular number and structure, reflecting bone absorption caused by enhanced osteoclast activity. Cardiovascular changes: blood pressure monitoring, cardiac ultrasound and vascular endothelial function testing reveal hemodynamic changes and decreased cardiac function adaptability in a microgravity environment. Metabolism and inflammation: Serum/tissue samples are analyzed for oxidative stress markers (such as MDA, SOD) and inflammatory factors (IL-6, TNF-α), and the mechanism of systemic physiological disorders induced by weightlessness is analyzed. This model is widely used in aerospace medical research, providing key experimental basis for formulating intervention strategies (such as exercise and drugs) to combat the negative effects of weightlessness. It also has important reference value in the fields of orthopedics and rehabilitation medicine. #animal behaviour, #behaviour analysis, #neuroscience research, #biomedical instrument, #experiment instrument, #laboratory instrument, #maze, #animal behaviour research, #brain research, #brain institute, #neuroscience research, #orthopedics, #rehabilitation, #areospace medical reseach, #animal behaviour analysis software; #animal behaviour analysis hardware, #Learning and memory, #Anxiety and depression, #Neuropsychiatric, #Drug addiction, #Parkinson, #Alzheimer [email protected]；[email protected]